| 鲎试剂用于细菌内毒素检测碳酸氢钠注射液的研究 |
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| 引用本文： | 赵蓝萌,杨戒骄.鲎试剂用于细菌内毒素检测碳酸氢钠注射液的研究[J].中国药学杂志,1999,34(2):116-118. |
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| 作者姓名： | 赵蓝萌 杨戒骄 |
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| 作者单位： | 深圳市人民医院药学部质检室 深圳 518019 |
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| 摘 要： | 目的：通过试验以确定碳酸氢钠注射液可用细菌内毒素代替传统的热原检查法。方法：用鲎试剂和家兔做对照试验确定灵敏度。结果：用灵敏度为0.125 EU·ml-1的鲎试剂进行内毒素检查比家兔灵敏度高12倍。结论：细菌内毒素检查法可以代替热原检查法。
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| 关 键 词： | 碳酸氢钠注射液 抑制/增强试验 细菌内毒素试验 热原试验 |
| 收稿时间： | 1998-04-06; |
Study on BET in sodium bicarbonate injection with TAL |
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| Zhao Xiaomeng.Study on BET in sodium bicarbonate injection with TAL[J].Chinese Pharmaceutical Journal,1999,34(2):116-118. |
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| Authors: | Zhao Xiaomeng |
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| Institution: | (Zhao XM),Yang Jiejiao(Yang JJ),Zhu Yongquan(ZhuYQ |
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| Abstract: | OBJECTIVE:To determine whether bacterial endotoxins test(BET) can replace the pyrogen test for the sodium bicarbonate injection.METHODS:The comparative experiment of tachypleus amebocyte lysate(TAL) and rabbits were studied to determine the sensitivity.RESULTS:The sensitivity of TAL test was 0.125 EU·ml-1,12 times higher than that of using rabbits.CONCLUSIONS:BET may replace pyrogen test. |
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| Keywords: | sodium bicarbonate injection inhibition/strengthen test bacterial endotoxins test pyrogen test |
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