南京地区结核分枝杆菌耐药监测疫情趋势分析

目的了解南京地区胸科医院结核病患者结核分枝杆菌对临床常用9种药物的耐药情况。方法对我院分离的结核分枝杆菌采用绝对浓度法对9种抗结核药物:链霉素、异烟肼、乙胺丁醇、利福平、对氨基水杨酸、丁胺卡那霉素、卷曲霉素、左氧氟沙星、对氨基水杨酸异烟肼进行药敏试验,同时用PNB、TCH进行菌种初步鉴定。结果 10014株结核分枝杆菌中,总耐药率38.42%(3847/10014),单耐药率最高为利福平(27.35%),最低为卷曲霉素(0.50%);2017株耐多药结核分枝杆菌对另外7种药物单耐药率最高为链霉素(56.22%),最低为卷曲霉素(1.69%),对9种药物全耐者有3株。结论结核分枝杆菌对多种药物耐药率高,应加强抗结核药物耐药性监测,根据药敏试验结果选择科学有效的化疗方案。

Research on drug resistance of mycobacterium tuberculosis in Nanjing area

Objective To analyze the drug resistance of mycobacterium tuberculosis （ MTB） for 9 type anti-tuberculosis drugs in Nanjing chest Hospital. Methods MTB strains were tested with absolute concentration method for 9 type anti-tuberculosis drugs, including SM, INH, EMB, RFP, PAS, AMK, CPM, LVFX and PSNZ. Results The total ratio of drug resistance for 9 type anti-tuberculosis drugs was 38. 42% （3847/10014）. The highest re-sistant rate was RFP （27. 35%）, and the lowest was CPM （0. 50%）. Of 2017 strains multidrug resistant tuberculo-sis （MDR-TB）, the highest resistant rate was SM （56. 22%）, and the lowest was CPM （1. 69%）. There were 3 strains of MDR-TB resistant to another 7 type anti-tuberculosis drugs. Conclusion MTB is highly resistant to a vari-ety of antibiotics. Monitoring of resistance to anti-tuberculosis drugs must be strengthened.