榄香烯联合奈达铂胸腔灌注治疗肺癌恶性胸水

目的观察榄香烯联合奈达铂胸腔灌注治疗恶性胸水的疗效。方法将65例肺癌恶性胸水患者随机分成联合治疗组(34例)和对照组(31例),联合组给予两药联合,对照组单纯给予奈达铂。结果联合组有效率为88.23%,对照组为58.06%,(P0.01)。联合组生活质量改善优于对照组(76.47%,61.29%),(P0.05)。主要不良反应有骨髓抑制、发热、胸痛、消化道反应等,联合组发热、胸痛发生率高于对照组(P0.05),经对症处理可较好控制。结论榄香烯联合奈达铂胸腔注射治疗肺癌恶性胸水疗效确切,改善晚期肿瘤患者的生存质量,毒副反应较低,安全有效。

Clinical research on Elemene combined with nedaplatin in the treatment of malignant pleural effusion in-duced by non-small cell lung cancer

Objective To observe the clinical efficacy of Elemene combined with nedaplatin in the treatment of malignant pleural effusion. Methods 65 patients with pleural effusion induced by lung cancer were randomly di-vided into the combined treatment group （34 cases） and the control group （31 cases）. The combined group was giv-en pleural infusion therapy of Elemene and nedaplatin, and the control group was given nedaplatin without Elemene. Results The total effective rate was 88. 23% in the combined group and 58. 06% in the control group （P〈0. 05）. The total modification rate was 76. 47% and 61. 29% respectively in the combined group and the control group （ P〈0. 05）. The main adverse reactions were bone marrow suppression, fever, stethalgia, and gastrointestinal reactions. The incidence of fever and stethalgia in the combined group was higher than in the control group （P〈0. 05）, but it＆amp;nbsp;could be relieved by reasonable treatment for the symptoms. Conclusion Elemene combined with nedaplatin is safe and effective for malignant pleural effusion by lung cancer, and this therapy can improve the quality of life of patients with advanced cancer.