沙培林联合卡铂治疗晚期肺癌恶性胸水的临床观察

目的 探讨沙培林联合卡铂治疗恶性胸腔积液的临床疗效.方法 将88例恶性胸水患者随机分为治疗组44例和对照组44例,治疗组采用沙培林联合卡铂胸腔注射,对照组单纯用卡铂治疗.结果 治疗组控制胸水的有效率为90.9%,对照组为61%,两者比较差异有显著性(P＜0.01).治疗组副作用为发热、胸痛、骨髓抑制和消化道反应,两组比较无显著性差异(P＞0.05).结论 沙培林联合卡铂胸腔注射能有效治疗恶性胸水,且简单易行,较单药卡铂疗效好.

Clinic Study on Treatment Malignant Thotacic Hydrops by Carboplatin Combined with Group A Streptococcus in Jection

Objective To evaluate the effect of carboplatin combined streptococcus for injection saintra thoracic instillation on lung cancer accompanied severe hydrothorax. Methods 88 patients with malignant thotacic hydrops in lung cancer were divided into two groups randomly. Then given streptococcus and carboplatin for injection intrathoracic instillation for treatment groups. only carboplatin for injection intrathoracic instillation for comparison groups. Results Total effct rate for carbopolatin combined with A streptococcus for injection is 90.9%. While that for carboplatin is 61%. There is so obvious difference between the two groups(P<0.01). and the bad response of treatment group is lower than that of comparison group. but There is no obvious difference between the two groups(P>0 05). The main side effects were fever, chest ache, arrest of bone marrow, digestive tract reaction. Conclusion Carboplatin combined streptococcus for injections aintrathoracic instillation on lung cancer accompanied severe hydrothorax is simple and effective, and it is better than that only carboplatin.