小柴胡汤对小鼠肉瘤S180的抑制作用和血浆内皮素的影响

目的：探讨小柴胡汤（ＸＣＨＴ）对鼠肉瘤Ｓ１８０的抑制作用及机制。方法：Ｃ体内实验，观察不同浓度ＳＣＨＴ浸膏对小鼠肉瘤Ｓ１８０的抑制作用和用放射免疫测定法（ＲＩＡ）测定荷瘤小鼠血交内皮素（ＥＴ）含量的变化。结果：高、中和低浓度ＸＣＨＴ（１．０ｇ／ｍｌ，０．５ｇ／ｍｌ和０．２５ｇ／ｍｌ）溶液治疗１０天后，对小鼠肉瘤Ｓ１８０有明显的抑掉作用，抑瘤率为４７．７－５６．６％。同时发现荷Ｓ１８０肉瘤小鼠血浆内

Effect of xiao chai hu tang on tumor weight andplasma endothelin content in mice bearing sarcoma180

Purpose: To study the antitumor effect of Xiao Chai Hu Tang (XCHT) on mice bearing sarcoma180 and its possible mechanism. Method: We observed the effect of XCHT extract on tumor weight and plasma endothelin content in mice bearing sarcoma180 by means of radioimmunoassay. Results: After treatment with XCHT solution of high, middle and low concentration (1000 mg. ml-1, 500 mg.ml-1, 250 mg.ml-1), XCHT could markedly inhibit S180 growth, the rate of inhibition ranged from 47 7 to 56 6 percent. Meanwhile we found the plasma endothelin content in bearing tumor mice was obviously higher than that of the control, while after treatment with XCHT of different concentration, the plasma endothelin level could be reduced to nearly normal or even lower than normal. Conclusion: XCHT had antitumor effect and its possible mechanism is mediated by lowering the plasma endothelin level in beraring tumor mice.