| Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma |
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| 引用本文： | Kazuko Uno,Yoshiki Suginoshita,Kazuhiro Kakimi,Fuminori Moriyasu,Mayumi Hirosaki,Taro Shirakawa,Tsunataro Kishida. Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma[J]. World journal of gastroenterology : WJG, 2005, 0(46) |
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| 作者姓名： | Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida |
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| 作者单位： | Louis Pasteur Center for Medical ResearchKyoto Japan，Department of Gastroenterology and HepatologyFaculty of Medicine，Kyoto University，Kyoto，Japan，Department of Gastroenterology and HepatologyFaculty of Medicine，Kyoto University，Kyoto，Japan，Department of Gastroenterology and HepatologyFaculty of Medicine，Kyoto University，Kyoto，Japan，Department of Health Promotion and Human BehaviorKyoto University Graduate School of Public Health，Kyoto，Japan，Department of Health Promotion and Human BehaviorKyoto University Graduate School of Public Health，Kyoto，Japan，Louis Pasteur Center for Medical ResearchKyoto，Japan |
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| 基金项目： | Supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (No.17606005 and 16201041) a Research Grant for Allergic Disease and Immunology from the Ministry of Health, Labour and Welfare of Japan (H16-Immunology-002) |
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| 摘 要： | AIM: To determine the utility of interferon (IFN) -α production capacity in patients with hepatitis C virus (HCV) infection for the measurement of immuno-surveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection. METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC). RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC. CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.
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| 关 键 词： | IFN-α production capacity Hepatitis C virus Hepatocellular carcinoma |
Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma |
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| Kazuko Uno,Tsunataro Kishida,Louis Pasteur Center for Medical Research,Kyoto,Japan Yoshiki Suginoshita,Kazuhiro Kakimi,Fuminori Moriyasu. Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma[J]. World journal of gastroenterology : WJG, 2005, 0(46) |
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| Authors: | Kazuko Uno Tsunataro Kishida Louis Pasteur Center for Medical Research Kyoto Japan Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu |
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| Affiliation: | Kazuko Uno,Tsunataro Kishida,Louis Pasteur Center for Medical Research,Kyoto,Japan Yoshiki Suginoshita,Kazuhiro Kakimi,Fuminori Moriyasu,Department of Gastroenterology and Hepatology,Faculty of Medicine,Kyoto University,Kyoto,Japan Mayumi Hirosaki,Taro Shirakawa,Department of Health Promotion and Human Behavior,Kyoto University Graduate School of Public Health,Kyoto,Japan |
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