| 尿酶测定用于32例氨基甙类肾毒性早期损害的观察 |
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| 引用本文： | 蔡湄,吴青刚,庞宁,魏有仁. 尿酶测定用于32例氨基甙类肾毒性早期损害的观察[J]. 中日友好医院学报, 1992, 0(Z1) |
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| 作者姓名： | 蔡湄 吴青刚 庞宁 魏有仁 |
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| 作者单位： | 中日友好医院检验科，中日友好医院儿科 |
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| 摘 要： | 采用尿N-乙酰氨基-β-D-氨基葡萄糖苷酶(NAG)检测对32例患者进行了用药前、后的连续观察。用庆大霉素前尿NAG的均值为21.98％U/g Cr;用药1d为89.92;用药3d为94.45;经统计学处理,自身配对比较,有显著性差异(用药前后t=3.108,P<0.01),证实NAG是观察庆大霉素早期肾毒性的灵敏指标。
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| 关 键 词： | N-乙酰氨基-β-D氨基葡萄糖苷酶 肾毒性 |
THE EARLY MONITORING OF AMINOGLYCOSIDE RENAL INJURY USING URINARY ENZYME DETERMINATION |
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| Cai Mei et al. THE EARLY MONITORING OF AMINOGLYCOSIDE RENAL INJURY USING URINARY ENZYME DETERMINATION[J]. Journal of China-Japan Friendship Hospital, 1992, 0(Z1) |
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| Authors: | Cai Mei et al |
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| Affiliation: | Department of Medical Laboratory |
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| Abstract: | The incidence of acute renal failure caused by aminoglycoside antibiotics was about 5-22% even under the therapeutic drug monitoring. Authors observed a group of patients (n=32) by sequential urinary enzyme determinations (NAG and LAP) before and after gentamicin injection. The urinary NAG/Creatinice indices varied from 21. 98 (mean value) to 89. 92 at the day after injection and elevated to 94.45 at the 3rd day (t=3.108, P<0.01). The importance of early monitoring of aminoglycoside renal injury using urinary enzyme determination was discussed. |
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