枯草杆菌二联活菌胶囊对肝硬化自发性腹膜炎患者血浆内毒素及炎症因子影响

目的：探讨枯草杆菌二联活菌肠溶胶囊对肝硬化并自发性腹膜炎（SBP）患者血浆内毒素及炎症因子的影响及临床疗效.方法：乙型肝炎肝硬化合并SBP患者70例随机分为观察组36例和对照组34例.两组患者均予以低盐饮食及常规治疗.观察组加服枯草杆菌二联活菌肠溶胶囊0.5 g,tid,连续4周.观察两组患者治疗前后血浆内毒素、IL-8和和TNF-α水平的变化,比较两组临床疗效和药品不良反应发生情况.结果：两组患者治疗后血浆内毒素、IL-8和TNF-α水平均较治疗前明显下降（P〈0.05）,观察组下降幅度明显高于对照组（P〈0.05）;观察组总有效率88.89%,明显高于对照组（P〈0.01）.两组患者治疗期间未见明显药品不良反应.结论：枯草杆菌二联活菌肠溶胶囊能降低肝硬化SBP患者血浆内毒素及炎症因子IL-8和TNF-α水平,减轻局部炎症反应,提高治疗有效率,能辅助治疗肝硬化自发性腹膜炎.

Effect of Bacillus Subtilis and Enterococcus Faecium Enteric coated Capsules on Plasma Levels of Endotoxin and Inflammatory Cytokine in Cirrhosis Patients with Spontaneous Bacterial Peritonitis

Objective： To explore the effect of bacillus subtilis and enterococcus faecium enteric-coated capsules （BSEFEC or Meichangan） on plasma levels of endotoxin and inflammatory cytokine in the cirrhosis patients with spontaneous bacterial peritonitis （SBP）. Method： Totally 70 cin＇hosis patients with SBP were divided into the observation group （36 cases） and the control group （34 cases）. All the patients were received the traditional treatment and low-salt diet. The patients in the observation group were with BSEFEC 0.5g tid, for 4 weeks. The plasma levels of endotoxin, IL-8 and TNF-a of the patients pre- and post-therapy, clinic effects and side effects were obseed. Result： In the two groups, the levels of endotoxin, IL-8 and TNF-a were decreased significantly post therapy than those pre-therapy （P 〈 0.05 and P 〈 0.01 ）, and the decrease was more obvious in the observation group than that in the control group （ P 〈 0.05 ）. The total effective rate of the observation group was significantly higher than that of the control group （P 〈 0.01 ）. There were no obvious ADR observed during the treatment in the two groups. Conclusion： BSEFEC can down-regulate the plasma levels of endotoxin, IL-8 and TNF-a, relieve the local inflammatory reaction, and improve the response rate, which can be used in the adjuvant therapy of spontemeaus bacterial peritonitis.