| 辛伐他汀片中某未知杂质LC-MS定性分析 |
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| 引用本文： | 胡兵,黄碧海,单晓芸,黄偲. 辛伐他汀片中某未知杂质LC-MS定性分析[J]. 中国药师, 2013, 16(9): 1357-1358 |
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| 作者姓名： | 胡兵 黄碧海 单晓芸 黄偲 |
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| 作者单位： | 1. 武汉市食品药品检验所,武汉,430012
2. 武汉宏韧医药科技有限公司 |
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| 摘 要： | 目的：对辛伐他汀片中某一未知杂质进行定性分析.方法：用HPLC-MS对辛伐他汀片中一未知杂质进行定性分析.结果：根据HPLC-MS信息确定杂质结构.结论：该杂质为辛伐他汀酸乙酯.
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| 关 键 词： | 辛伐他汀片 未知杂质 定性分析 液质联用 |
| 修稿时间： | 2013-07-05 |
Qualitative Analysis of an Unkown Impurity in Simvastatin Tablets by LC-MS |
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| Hu Bing , Huang Bihai , Shan Xiaoyun , Huang Cai. Qualitative Analysis of an Unkown Impurity in Simvastatin Tablets by LC-MS[J]. China Pharmacist, 2013, 16(9): 1357-1358 |
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| Authors: | Hu Bing Huang Bihai Shan Xiaoyun Huang Cai |
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| Affiliation: | Blha Shan Xlaoyun, Huang Cai2 (1. Wuhan Institute for Food and Drug Control, Wuhan 430012, China ;2. Wuhan Hongren Medicine Teehnology Co. Ltd. ) |
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| Abstract: | ABSTRACT Objective: To qualitatively analyze a certain unknown impurity in simvastatin tablets. Method:The structure of the unknown impurity was qualitatively analyzed by HPLC-MS.Result:The structure of the impurity was determined preliminarily by the information of HPLC-MS. Conclusion:The impurity is defined as simvastatin acid ester. |
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| Keywords: | Simvastatin tablets Unknown impurity Qualitative analysis LC-MS |
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