Dissociation Between Ion Permeability and the Lethal Action of Polyene Antibiotics on Candida albicans |
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| Authors: | Winston C Chen Dong-Lang Chou and David S Feingold |
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| Institution: | 1Departments of Dermatology and Medicine, Boston University School of Medicine, and Boston Veterans Administration Hospital, Boston, Massachusetts 02130 |
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| Abstract: | Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs. |
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