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Direct antiviral treatment of chronic hepatitis C in heart transplant recipients |
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| Authors: | Martina Vitrone Roberto Andini Irene Mattucci Ciro Maiello Luigi Atripaldi Emanuele Durante‐Mangoni Rosa Zampino |
| Affiliation: | 1. Internal Medicine, University of Campania ‘L. Vanvitelli’, Napoli, Italy;2. Transplant Surgery, AORN Ospedali dei Colli, Napoli, Italy;3. Clinical Biochemistry, AORN Ospedali dei Colli, Ospedale Monaldi, Napoli, Italy;4. Infectious and Transplant Medicine, AORN Ospedali dei Colli, Ospedale Monaldi, Napoli, Italy |
| Abstract: | Direct‐acting antiviral agents (DAAs) are a safe and effective treatment for chronic hepatitis C (CHC). This may be particularly valuable for patients with severe comorbidities or baseline conditions, including non‐liver solid organ transplant. We report cases of two heart transplant recipients with CHC treated with DAAs (sofosbuvir and daclatasvir) achieving sustained virological response. Treatment was well tolerated and no relevant side effects were observed. The drug‐drug interactions and graft function were carefully monitored. |
| Keywords: | chronic hepatitis C direct‐acting antiviral agents (DAAs) heart transplant sustained virological response (SVR) |