皮肤角质层及其损伤的研究进展

皮肤角质层（SC）位于表皮的最外层，具有独特的结构、物理和生化特性。可能引起由终末分化的角质细胞和镶嵌于其中的脂质基质组成，是机体的重要保护屏障，能抵抗外源性有害物质渗透和防止体内水分丢失。近年的研究表明，外界各种刺激因素如紫外线辐射、机械摩擦、有机溶剂等均可能引起SC结构和功能的损伤。萁损伤-修复过程复杂，机制尚不清楚，多种细胞因子、神经酰胺等均可能参与了此过程的调控。作者对SC的结构与功能、损伤与修复作一综述。

Research advances on dermal stratum corneum and its injury

Stratum corneum,the outermost layer of the mammalian skin, has its unique structural,biophysical and biochemical characteristics.The form of stratum corneum is a continuous sheath of protein-enriched corneocytes embedded in an intercellular matrix enriched in nonpolar specialized lipids.It provides an impermeable barrier from exogenous noxious substances and prevents the body from transdermal water loss.Recent researches suggest that its morphological and functional abnormalities can be induced by various environmental effects such as ultraviolet radiation,mechanical friction,organic solvents,etc.However,the mechanism of the injury-repair process remains unclear.Several cytokines and ceramide may be involved in the regulation.