IL-33和IL1RL1基因单核苷酸多态性与特应性皮炎相关性研究

目的:分析IL-33和IL1RL1基因单核苷酸多态性(SNPs)与特应性皮炎(AD)的相关性。方法:PCR-SSP方法检测89例AD患者和138名正常对照组受试者IL-33和IL1RL1编码基因的等位基因和基因型频率。结果:AD患者的IL-33 rs1800925 C等位基因的频率高于对照组,而T等位基因和rs764706552等位基因G低于对照组(均P<0.001)。IL-33 rs1800925基因型CC和rs764706552基因型CG与AD显著正相关(均P<0.001)。两组患者的IL1RL1基因的等位基因和基因型频率无明显差异(均P>0.05)。结论:IL-33基因可能与AD的发病相关。

Correlation between single nucleotide polymorphisms of IL-33/IL1RL1 genes and atopic dermatitis

Objective: To analyze the association between the loci polymorphisms of IL-33, IL1RL1 gene and atopic dermatitis (AD). Methods: The allele and genotype frequencies of IL-33 and IL1RL1 encoding genes in 89 AD patients and 138 normal controls were detected by PCR-SSP. Results: The allele frequency of IL-33 gene rs1800925 C in the AD patients was higher than that in the controls. The allele frequencies of IL-33 gene rs1800925 T and rs764706552 G in the AD patients were lower than those in the controls (Ps<0.001). The CC and CG genotypes frequencies of IL-33 rs1800925 and rs764706552 were significantly positively correlated with AD (Ps<0.001). There was no significant difference in the frequencies of alleles and genotypes of IL1RL1 gene between the two groups (Ps>0.05). Conclusion: rs1800925 and rs764706552 SNPs of IL-33 gene may be associated with the development of AD.