miR-132 Targets FOXA1 and Exerts Tumor-Suppressing Functions in Thyroid Cancer |
| |
Authors: | Xin Chen Mingzhe Li Hongwei Zhou Li Zhang |
| |
Institution: | * Department of Radiology, the First Hospital of Jilin University, Changchun, Jilin, P.R. China? China–Japan Union Hospital of Jilin University, Changchun, P.R. China |
| |
Abstract: | MicroRNA-132 (miR-132) has been demonstrated to be a tumor suppressor in several types of tumors. However,
the expression and the role of miR-132 in human thyroid cancer are still poorly understood. The aim of the
present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We
found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines.
Function assays showed that overexpression of miR-132 in TPC1 cells inhibited cell proliferation, migration,
and invasion. Forkhead box protein A1 (FOXA1) was identified as a direct target of miR-132 in thyroid cancer
cells. Knockdown of FOXA1 in TPC1 cells significantly inhibited cell proliferation, migration, and invasion,
which mimicked the suppressive effect induced by miR-132 overexpression. Restoration of FOXA1 expression
partially reversed the suppressive effect induced by miR-132 overexpression. Taken together, these results suggested that miR-132 acts as a tumor suppressor in thyroid cancer through targeting FOXA1. |
| |
Keywords: | MicroRNAs miR-132 Thyroid cancer FOXA1 |
|
| 点击此处可从《Oncology research》浏览原始摘要信息 |
| 点击此处可从《Oncology research》下载免费的PDF全文 |
|