肌钙蛋白T和CRP与NT-proBNP联合检测在慢性心力衰竭早期诊断的价值

目的 探讨肌钙蛋白T(cTnT)、C反应蛋白(CRP)和氨基末端脑利钠肽(NT-proBNP)联合检测应用慢性心力衰竭(CHF)早期诊断的临床价值,为CHF早期诊断提供参考依据。 方法 选取海口市第三人民医院自2015年5月—2017年5月间初诊为CHF住院患者90例作为观察组,选取同期健康体检者60例作为对照组,分别测定2组研究对象的cTnT、CRP、NT-proBNP指标水平差异,同时比较不同NYHA分级CHF患者3项指标的差异。 结果 NYHA分级越高则3项指标的含量越高,不同分级间指标差异有统计学意义(均P<0.05);NYHA-Ⅰ级患者CRP、NT-proBNP指标远高于健康体检组,差异具有统计学意义(P<0.05),cTnT指标2组差异无统计学意义(P>0.05);经过Spearman秩相关分析显示心脏分级与NT-proBNP、CRP、CTnT均呈正相关关系(r=0.875、0.412、0.312,均P<0.05),其中相关性较强为NT-proBNP。 结论 NT-proBNP是评估心脏功能的重要指标;cTnT、CRP联合NT-proBNP检测能够准确诊断CHF患者,同时能够对不同病情程度进行分级,为临床治疗提供可靠依据。 

Value study of combined detection of cTnT,CRP and NT-proBNP in early diagnosis of chronic heart failure

Objective To explore the clinical value of combined detection of troponin T(cTnT), C-reactive protein(CRP) and amino-terminal brain natriuretic peptide(NT-proBNP) in early diagnosis of chronic heart failure(CHF), and provide reference for early diagnosis of CHF. Methods Ninety patients with CHF in Haikou Third People's Hospital from May 2015 to May 2017 were selected as observation group. Sixty healthy people were selected as control group during the same period. The levels of cTnT, CRP and NT-proBNP of the two groups were measured, and the differences of three indicators in different NYHA grades with CHF patients were compared. Results The higher the NYHA grade, the higher the content of the three indicators. There were significant difference among different grades(all P<0.05). The CRP and NT-proBNP indicators of NYHA-I patients were significantly higher than those of healthy group(P<0.05), and there was no significant difference in cTnT indicators between the two groups(P>0.05). Spearman rank correlation analysis indicated that the cardiac grading showed a significant positive correlation with NT-proBNP, CRP and CTnT(r=0.875, 0.412, 0.312, all P<0.05). Conclusion NT-proBNP is an important indicators for evaluating cardiac function. Combined detection of cTnT, CRP and NT-proBNP can accurately diagnose CHF patients, and can grade different degrees of disease, providing reliable basis for clinical treatment.