浅蓝霉素类化合物合成研究进展

浅蓝霉素类化合物是一类微生物产生的生物碱，其分子结构中多含有一个2,2'-联吡啶母核。活性研究表明该类化合物多数具有良好的抗菌、肿瘤细胞毒和免疫调节等生物活性，合成化学家对此类化合物进行了全合成及其合成方法学的探索与研究。本文综述了此类生物碱的合成研究进展，重点介绍了浅蓝霉素A和E的全合成方法以及合成此类化合物的意义，展望了合成此类化合物的良好前景。

Research progress on the synthesis of caerulomycins

Caerulomycins are a kind of natural alkaloids featuring a 2,2'-bipyridine scaffold. Caerulomycins and their analogues exhibited potential bioactivities such as antimicrobial, cytotoxic, and immunosuppressive activities. Synthetic chemists have explored synthetic methods and synthesized these compounds. The synthetic methods and the significance of caerulomycins focusing on caerulomycins A and E were reviewed in this paper. The prospects for the synthesis of such compounds were expected.