康复新液治疗复发性口腔溃疡患儿的临床效果研究

目的 探讨康复新液对复发性口腔溃疡患儿炎症因子、口腔微生态、免疫功能及生活质量的影响。 方法 随机数字法将2017年1月—2019年4月河南省儿童医院东区医院诊治的102例复发性口腔溃疡患儿分为2组,每组51例。对照组给予复合维生素B,观察组在此基础上给予口服康复新液。观察2组炎症、口腔菌群、免疫指标、生活质量的变化。 结果 治疗后,2组血清TNF-α、IL-6、IL-2水平均降低(均P<0.05),且观察组低于对照组(均P<0.05)。治疗后,观察组韦荣氏菌含量由(7.54±1.43)lg copies/mL升高至(8.86±1.64)lg copies/mL,高于对照组的(8.15±1.57)lg copies/mL(t=2.233,P=0.028),链球菌含量由(6.98±1.21)lg copies/mL升高至(8.15±1.58)lg copies/mL,高于对照组的(7.46±1.40)lg copies/mL(t=2.334,P=0.022)。治疗后,2组CD3+、CD4+、CD4+/CD8+、CD8+、SF-36、OHIP-14水平均改善,且观察组改善效果优于对照组(均P<0.05)。 结论 康复新液可有效改善复发性口腔溃疡患儿的炎症、口腔微生态平衡、机体免疫功能及生活质量。 

Clinical Effect of Kangfuxin Liquid on Children with Recurrent Oral Ulcer

Objective To investigate the effects of Kangfuxin Liquid on inflammatory factors, oral microecology, immune function and quality of life in children with recurrent oral ulcer. Methods A total of 102 children with recurrent oral ulcer who were treated in our hospital from January 2017 to April 2019 were enrolled in the study. The 102 children were randomly divided into two groups by random number method, 51 cases in each group. The control group received multivitamin B treatment. The observation group was given Kangfuxin Liquid. After treatment, changes in inflammatory factor levels, oral flora, immune indicators, and quality of life in the two groups were observed. Results After treatment, the serum levels of TNF-α, IL-6 and IL-2 in both groups were decreased(all P<0.05), and the levels in the observation group were lower than those in the control group(all P<0.05). After treatment, the content of virogenes in the observation group increased from(7.54±1.43)lg copies/mL to(8.86±1.64)lg copies/mL, higher than that in the control group(8.15±1.57)lg copies/mL(t=2.233, P=0.028), and the content of streptococcus increased from(6.98±1.2)lg copies/mL to(8.15±1.58)lg copies/mL, Higher than the control group(7.46±1.40)lg copies/mL(t=2.334, P=0.022). After treatment, the levels of CD3+, CD4+, CD4+/CD8+, CD8+, SF-36 and OHIP-14 in both groups were improved, and the improvement effect in the observation group was better than that in the control group(all P<0.05). Conclusion Kangfuxin Liquid can effectively improve inflammatory factor levels, oral micro-ecological balance, immune function and quality of life in children with recurrent oral ulcer.