沙库巴曲缬沙坦对射血分数降低的缺血性心肌病患者心肌损伤和炎症因子的影响

目的 探究沙库巴曲缬沙坦对射血分数降低的缺血性心肌病患者的心肌损伤和炎症指标的影响,为其治疗缺血导致的心力衰竭提供依据。 方法 选择2019年1—12月于杭州师范大学附属医院治疗的射血分数降低的缺血性心肌病患者84例作为研究对象,利用随机数字表法将其分为观察组(42例)和对照组(42例)。观察组采用沙库巴曲缬沙坦进行治疗,对照组采用缬沙坦进行治疗,比较2组治疗4周后心肌损伤和炎症指标。 结果 治疗4周后,观察组NT-proBNP平均水平为(1 726.36±492.37)pg/mL、cTnI平均水平为(19.27±4.38)ng/L,对照组上述指标分别为(2 833.37±503.44)pg/mL、(22.39±5.02)ng/L,2组比较差异有统计学意义(t值分别为10.188、3.035,均P<0.05)。治疗后观察组hs-CRP水平为(5.48±1.28)mg/L、IL-6水平为(18.36±3.38)pg/mL、TNF-α水平为(5.32±1.27)pg/mL、IFN-γ水平为(6.67±1.17)pg/mL,对照组上述指标分别为(6.85±1.37)mg/L、(21.29±3.22)pg/mL、(8.34±1.87)pg/mL、(9.30±1.20)pg/mL,观察组炎症因子水平均低于对照组(均P<0.05)。 结论 沙库巴曲缬沙坦能够缓解缺血性心肌病患者心肌损伤,在短时间内降低心力衰竭状态下炎症因子水平。 

The effect of sacubitril/valsartan on myocardial injury and inflammatory factors in ischemic cardiomyopathy with reduced ejection fraction

Objective To explore the effect of sacubitril/valsartan on myocardial injury and inflammatory indexes in patients with ischemic cardiomyopathy with reduced ejection fraction, so as to provide evidence for the treatment of heart failure caused by ischemia. Methods Eighty-four patients with ischemic cardiomyopathy complicated with heart failure who were hospitalized in the Affiliated Hospital of Hangzhou Normal University from January 2019 to December 2019 were selected as the research object. They were divided into observation group(42 cases) and control group(42 cases) by random number table method. The observation group was treated with sacubitril/valsartan, and the control group was treated with valsartan. Myocardial injury and inflammation indexes were compared between the two groups after 4 weeks of treatment. Results After 4 weeks of treatment, the average level of N-terminal prohormone of brain natriuretic peptide(NT-proBNP) in the observation group was(1 726.36±492.37) pg/mL, the average level of cardiac troponin I(cTnI) was(19.27±4.38) ng/L, and the above indexes in the control group were(2 833.37±503.44) pg/mL,(22.39±5.02) ng/L, respectively, the difference was statistically significant(t=10.188 and 3.035, all P<0.05). In the observation group, the high-sensitivity C-reactive protein(hs-CRP) level was(5.48±1.28) mg/L, IL-6 level was(18.36±3.38) pg/mL, TNF-α level was(5.32±1.27) pg/mL, and IFN-γ level was(6.67±1.17) pg/mL, the above indexes of the control group were(6.85±1.37) mg/L,(21.29±3.22) pg/mL,(8.34±1.87) pg/mL,(9.30±1.20) pg/mL, respectively. The level of inflammatory factors in the observation group were lower than those in the control group(all P<0.05). Conclusion sacubitril/valsartan can repair myocardial injury in patients with ischemic cardiomyopathy and reduce inflammation in heart failure in a short time.