急性缺血性脑卒中患者血清胱抑素C与脑微出血的相关性研究

目的 探究急性缺血性脑卒中患者脑微出血(CMB)的危险因素以及血清胱抑素C (Cys-C)水平与CMB严重程度的相关性。 方法 选取2016年10月—2019年7月于宁波市北仑区人民医院神经科住院治疗的急性缺血性脑卒中患者120例,住院7 d后行MRI-SWI序列检查,根据结果分为CMB组(39例)和无CMB组(81例),比较2组临床资料和检验结果的差异。以差异有统计学意义的变量为自变量,采用多因素logistic回归分析分析CMB发生的危险因素,Spearman相关性分析分析Cys-C水平与CMB数量的关系。 结果 CMB组年龄、SBP、DBP、hs-CRP均高于无CMB组(均P<0.05)。CMB组Cys-C水平为(1.23±0.11) mg/dL,无CMB组为(1.02±0.11) mg/dL,差异具有统计学意义(t=9.754,P<0.05)。CMB组eGFR水平为(63.52±18.02) mL/(min·1.73 m2),无CMB组为(76.44±18.42) mL/(min·1.73 m2),差异具有统计学意义(t=3.624,P<0.05)。多因素logistic回归分析显示SBP、eGFR、Cys-C是急性缺血性脑卒中患者CMB的独立危险因素,Spearman相关性分析显示Cys-C水平与CMB数量呈正相关(r=0.482,P<0.001)。 结论 血清胱抑素C与急性缺血性脑卒中患者CMB程度呈正相关,可以用于预测CMB的发生,早期筛选高危患者。 

The correlation between serum cystatin C and cerebral microhemorrhage in patients with acute ischemic stroke

Objective To explore the risk factors of cerebral microhemorrhage(CMB) in patients with acute ischemic stroke and the correlation between the level of serum cystatin C(Cys-C) and the severity of CMB. Methods From October 2016 to July 2019, 120 patients with acute ischemic stroke hospitalized in the Department of Neurology of Beilun District People's Hospital were selected. After 7 days of hospitalization, MRI-SWI sequence was performed. According to the results, the patients were divided into CMB group(39 cases) and non-CMB group(81 cases). The differences of clinical data and test results between the two groups were compared. Taking statistically significant variables as independent variables, multivariate logistic regression was used to analyze the risk factors of CMB, and Spearman correlation was used to analyze the relationship between Cys-C level and the number of CMB. Results The age, SBP, DBP and hs-CRP of CMB group were higher than those of non-CMB group(all P<0.05). The Cys-C level of CMB group was(1.23±0.11) mg/dL, and that of non-CMB group was(1.02±0.11) mg/dL, the difference was statistically significant(t=9.754, P<0.05). The eGFR level of CMB group was(63.52±18.02) mL/(min·1.73 m2), and that of non CMB group was(76.44±18.42) mL/(min·1.73 m2), the difference was statistically significant(t=3.624, P<0.05). The result of Multivariate logistic regression showed that SBP, eGFR, Cys-C were independent risk factors of CMB in patients with acute ischemic stroke, and the Spearman correlation analysis showed that Cys-C level was positively correlated with the number of CMB(r=0.482, P<0.001). Conclusion Serum Cys-C has a positive correlation with CMB in patients with acute ischemic stroke, which can be used as an independent risk factor for CMB.