抗结核药品对肠道菌群的改变及其对机体的影响

肠道菌群的结构和代谢产物与人体互相作用,维持肠道屏障稳态,促进全身营养代谢与免疫平衡,参与多种系统及组织、器官的病理生理过程,在结核感染、发病、治疗及转归过程中发挥重要作用,但是抗结核药品对肠道菌群的影响研究刚刚起步。作者综述肠道菌群在肠道屏障稳态中的作用,进而梳理和总结抗结核药品对肠道菌群影响的研究成果,并最终扩展至相关临床问题,讨论肠道菌群改变对机体的广泛影响。

Effects of anti-tubercular agents on intestinal flora and its influence on the organism

The structure and metabolites of intestinal flora interact with the human body, to maintain the steady state of intestinal barrier, promote the balance of nutrition metabolism and immunity, and take participate in the pathological and physiological processes of various systems, tissues and organs. It has significant effect on the process of TB infection, pathogenesis, treatment and prognosis. However, the study of the effect of anti-tubercular agents on intestinal flora is limited. The authors reviewed the effect of intestinal flora on steady state of intestinal barrier, summarized the research results of the effect of anti-tubercular agents on intestinal flora, expanded related clinical issues, and discussed the extensive effect of intestinal flora changes on the organism.