鲍曼不动杆菌碳青霉烯酶及流行分布研究

鲍曼不动杆菌是非发酵的革兰阴性细菌，一种机会性感染的病原体，可以引起血流、伤口感染和机械相关性肺炎并 能引起院内ICU科室的暴发感染，因其极强的获得耐药的能力成为全球棘手的病原体。近些年碳青霉烯类耐药的鲍曼不动杆菌 (CRAB)和多重耐药的鲍曼不动杆菌(MDRAB)逐渐增加，日渐成为临床上治疗的难题，其耐药机制主要是由于碳青霉烯酶的产 生。迄今为止，已在鲍曼不动杆菌中发现多种类型的碳青霉烯酶，本文就主要的碳青霉烯酶和流行分布特点加以概述。

Research of carbapenemases and their epidemic distribution in Acinetobacter baumannii

Acinetobacter baumannii (A. baumannii) is a non-fermentative, Gram-negative coccobacillus that can cause catheter-related bloodstream, wound infections, ventilator-associated pneumonia, and the outbreak infections in ICU. A. baumannii has emerged as one of the most troublesome pathogens globally owing to its remarkable ability to acquire resistance determinants. But during the last two decades, the increase of carbapenemresistant A. baumannii (CRAB) and multidrug-resistant of A. baumannii (MDRAB) become a problem of clinical treatment. Carbapenem resistance in A. baumannii is mainly mediated by the production of carbapenemases. Up to now, many types of carbapenemases have been found in A. baumannii. In this paper, the major carbapenemases and their distribution were reviewed.