| 长链非编码RNA在糖尿病视网膜病变发病机制中的作用 |
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| 引用本文： | 王中原,孙劲禹,谢田华,殷丽,姚勇.长链非编码RNA在糖尿病视网膜病变发病机制中的作用[J].眼科新进展,2020,0(5):487-491. |
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| 作者姓名： | 王中原 孙劲禹 谢田华 殷丽 姚勇 |
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| 作者单位： | 214023 江苏省无锡市，南京医科大学附属无锡人民医院 |
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| 基金项目： | 国家自然科学基金面上项目(编号81770941);江苏省科教强卫重点学科项目(编号ZDXKC2016008)。 |
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| 摘 要： | 糖尿病视网膜病变(diabetic retinopathy,DR)是一种严重的糖尿病微血管并发症,是糖尿病患者失明的主要原因之一。长链非编码RNA(long non-coding RNA,lncRNA)是一类核苷酸数大于200且不编码蛋白质的RNA,在多种生理和病理过程中发挥重要作用。最新研究表明,在糖尿病及其相关微血管并发症中广泛存在lncRNA的异常表达。本文将对目前DR相关lncRNA的基因组起源以及其在DR发生发展中的分子机制及调控作用进行综述,并讨论lncRNA在DR诊断和治疗中的前景。
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| 关 键 词： | 糖尿病视网膜病变 长链非编码RNA 基因调控 |
Research progress on role of lncRNA in diabetic retinopathy |
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| WANG Zhongyuan,SUN Jinyu,XIE Tianhua,YIN Li,YAO Yong.Research progress on role of lncRNA in diabetic retinopathy[J].Recent Advances in Ophthalmology,2020,0(5):487-491. |
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| Authors: | WANG Zhongyuan SUN Jinyu XIE Tianhua YIN Li YAO Yong |
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| Institution: | Wuxi People’s Hospital Affiliated to Nanjing Medical University,Wuxi 214023,Jiangsu Province,China |
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| Abstract: | Diabetic retinopathy (DR) is a severe diabetic microvascular complication, and is one of the major reasons for blindness in patients with diabetes mellitus. Long non-coding RNA (lncRNA) is a kind of RNA with more than 200 nucleotides and without protein coding, and plays a significant role in multiple physiological and pathological processes. Recent studies show aberrant expression of lncRNA has been widely observed in patients with diabetes mellitus and diabetes related microvascular complications. This article reviews the genomic origins of DR-related lncRNA and their molecular mechanisms and regulatory roles in the development of DR, and discusses the potential of lncRNA in the diagnosis and treatment of DR. |
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| Keywords: | iabetic retinopathy lncRNA gene regulation |
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