| 胰高血糖素样肽-1受体PET/CT定位诊断胰岛素瘤的技术规范 |
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| 引用本文： | 罗亚平,李方,于淼,邢小平,张太平,赵玉沛. 胰高血糖素样肽-1受体PET/CT定位诊断胰岛素瘤的技术规范[J]. 协和医学杂志, 2020, 11(4): 486-491. DOI: 10.3969/j.issn.1674-9081.2020.04.022 |
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| 作者姓名： | 罗亚平 李方 于淼 邢小平 张太平 赵玉沛 |
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| 作者单位： | 1.中国医学科学院 北京协和医学院 北京协和医院核医学科, 北京 100730 |
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| 基金项目： | 国家自然科学基金81501515公益性行业科研专项201402001 |
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| 摘 要： | 胰岛素瘤的诊断和手术治疗依赖于准确的影像学检查定位。以胰腺β细胞为靶点的胰高血糖素样肽-1受体(glucagon-like peptide-1 receptor, GLP-1R)是近年来胰岛素瘤影像研究中的亮点, 推荐临床推广使用68Ga-exendin-4进行GLP-1R正电子发射断层显像/计算机体层成像(positron emission tomography/computed tomography, PET/CT)来定位诊断胰岛素瘤。本文介绍GLP-1R显像在胰岛素瘤中的应用概况, 并以68Ga-exendin-4 GLP-1R PET/CT显像为例, 介绍该技术的操作规范, 以期为临床提供借鉴。
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| 关 键 词： | 胰高血糖素样肽-1受体 68Ga-exendin-4 胰岛素瘤 技术 |
| 收稿时间： | 2018-05-29 |
Procedure Guideline of Glucagon-like Peptide-1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma |
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| Abstract: | The diagnosis and surgical treatment of insulinoma is dependent on accurate localization with imaging modalities. Glucagon-like peptide-1 receptor (GLP-1R) imaging that targets pancreatic β cells has been highlighted for detecting insulinomas in recent years. Since the high sensitivity and specificity (se. 99%, sp. 100%) of GLP-1R imaging in localizing insulinoma, GLP-1R positron emission tomography/computed tomography (PET/CT) with 68Ga-exendin-4 is recommended to be introduced into clinical practice. This paper introduced the application of GLP-1R imaging in insulinoma, and took the GLP-1R PET/CT with 68Ga-exendin-4 as an example to elaborate the operation standard of this technique, aiming to provide a reference for clinical practice. |
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