乌鲁木齐市维吾尔族围绝经期女性代谢综合征的激素水平研究

目的 探讨乌鲁木齐市维吾尔族围绝经期女性代谢综合征(metabolic syndrome,Mets)患病率及其激素水平变化。 方法 选取2018年1—6月就诊于新疆医科大学第一附属医院及体检中心的367例维吾尔族女性为研究对象。根据月经状态分为绝经前组61例、围绝经期244例和绝经后早期组62例,比较并分析不同月经状态Mets激素水平变化。 结果 ①乌鲁木齐市维吾尔族40~60岁女性代谢综合征的发生率为16.1%,绝经后女性发病率(22.6%)高于绝经前(4.9%)和围绝经期(17.2%)女性。②绝经前代谢综合征组与对照组的性激素水平比较,差异无统计学意义;围绝经期代谢综合征组与对照组比较,卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)差异无统计学意义(均P>0.05),雌二醇(E2)、E2/T差异有统计学意义(均P<0.05);绝经后早期组中代谢综合征组同对照组比较,E2/T经U检验差异有统计学意义(P<0.05)。③围绝经期和绝经后早期代谢综合征组女性激素FSH、E2、E2/T比较差异有统计学意义(均P<0.05)。 结论 Mets的患病率随着绝经状态的改变逐渐增加。绝经后早期组患病率高于绝经前组和围绝经期女性。围绝经期组中代谢综合征的发生可能与E2降低和E2/T升高有关,绝经后早期组可能与E2和T的比例失调有关。 

Study on the hormone level of perimenopausal uygur women metabolic syndrome in Urumqi

Objective To investigate the prevalence of metabolic syndrome(Mets) and the changes of hormone levels in perimenopausal women of uygur nationality in Urumqi. Methods A total of 367 uygur perimenopausal women who were admitted to the first affiliated hospital and physical examination center of Xinjiang Medical University from January to June 2018 were selected as research objects. According to the menstrual state, the patients were divided into pre-menopausal group(61 cases), perimenopause group(244 cases) and early postmenopausal group(62 cases). The changes of Mets hormone levels in different menstrual states were compared and analyzed. Results ① The incidence of Mets was 16.1% in uygur women aged 40-60 years in Xinjiang. The incidence rate of postmenopausal women(22.6%) was higher than that of premenopausal women(4.9%) and perimenopausal women(17.2%). ② There was no statistically significant difference in sex hormone levels between each case group and the control group before menopause. There was no significant difference in FSH, LH and T(P>0.05), while there was significant difference in E2 and E2/T(all P<0.05) between the perimenopausal metabolic group and the control group. Compared with the control group, E2/T in the Mets group and the early postmenopausal group was statistically significant by U test(P<0.05). ③ There were statistically significant differences in FSH, E2, E2/T between perimenopausal and early postmenopausal Mets groups(all P<0.05). Conclusion The prevalence of Mets increases with the change of menopause. The prevalence of postmenopausal early group is higher than that of premenopausal and perimenopausal women. The occurrence of metabolic syndrome may be related to the decrease of E2 and the increase of E2/T in the perimenopause group, and the imbalance of E2 and T in the early postmenopausal group.