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针药并用诱导自噬对ApoE基因敲除小鼠认知功能的影响
引用本文:吕美娟,马贤德,任路. 针药并用诱导自噬对ApoE基因敲除小鼠认知功能的影响[J]. 吉林大学学报(医学版), 2020, 46(6): 1124-1130. DOI: 10.13481/j.1671-587x.20200603
作者姓名:吕美娟  马贤德  任路
作者单位:辽宁中医药大学针灸推拿学院,辽宁 沈阳 110032
辽宁中医药大学教学实验中心,辽宁 沈阳 110032
辽宁中医药大学研究生院,辽宁 沈阳 110032
基金项目:国家自然科学基金项目资助课题(81373718);国家重点研发计划项目资助课题(2108YFC1704300);辽宁省特聘教授项目资助课题
摘    要:目的观察针药并用干预手段对ApoE基因敲除小鼠海马组织中自噬水平的影响,探讨针药并用干预手段通过磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路发挥调控自噬的作用机制。

关 键 词:针刺  中药  认知功能  自噬  磷脂酰肌醇-3-激酶  蛋白激酶B  哺乳动物雷帕霉素靶蛋白  
收稿时间:2020-02-05

Effect of acupuncture combined with medicine-induced autophagy on cognitive function of mice with ApoE gene knockout
Meijuan LU,Xiande MA,Lu REN. Effect of acupuncture combined with medicine-induced autophagy on cognitive function of mice with ApoE gene knockout[J]. Journal of Jilin University: Med Ed, 2020, 46(6): 1124-1130. DOI: 10.13481/j.1671-587x.20200603
Authors:Meijuan LU  Xiande MA  Lu REN
Affiliation:School of Acupuncture and Massage,Liaoning University of Traditional Chinese Medicine,Shengyang 110032,China
Teaching Experiment Center,Liaoning University of Traditional Chinese Medicine,Shengyang 110032,China
Graduate School,Liaoning University of Traditional Chinese Medicine,Shengyang 110032,China
Abstract:ObjectiveTo observe the effect of acupuncture combined with medicine on the autophagy in hippocampus tissue of the mice with ApoE gene knockout, and to explore the mechanism of acupuncture combined with medicine in regulating the autophagy through the phosphatidylinosital-3-kinase(PI3K)/protein kinase B(AKT)-mamalian target of repamycin(mTOR) signaling pathway.
Keywords:acupuncture  traditional Chinese medicine  cognitive function  autophagy  phosphatidylinosital-3-kinase  protein kinase B  mamalian target of repamycin  
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