Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway |
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Authors: | Wei Song Jia-Zhuan Mei Mingzhi Zhang |
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Institution: | * The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China? Department of Oncology, The People’s Hospital of Zhengzhou, Zhengzhou, Henan, P.R. China? Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China |
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Abstract: | Accumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important
regulatory role in cancers. However, the expression and biological functions of PlncRNA-1 in colorectal cancer
(CRC) are still unclear. In the present study, we determined the expression of PlncRNA-1 in CRC and explored
the function of PlncRNA-1 on CRC cell progression. The results showed that PlncRNA-1 was significantly
increased in CRC tissues and cell lines; high PlncRNA-1 expression was associated with depth of invasion,
lymph node metastasis, and TNM stage of CRC patients. Kaplan–Meier curve analysis showed that patients
with high PlncRNA-1 expression had a poor overall survival. PlncRNA-1 knockdown remarkably reduced
cell proliferation, migration, and invasion and promoted cell apoptosis in vitro. In vivo xenograft experiments
showed that PlncRNA-1 inhibition significantly suppressed tumor growth. Finally, we used an agonist (740Y-P)
of the PI3K/Akt signaling pathway; function assays showed that PlncRNA-1 exerted its effects by targeting the
PI3K/Akt signaling pathway in CRC. Taken together, our data suggested that PlncRNA-1 might act as an oncogene in CRC progression and serve as a potential biomarker and therapeutic target for the treatment of CRC. |
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Keywords: | Long noncoding RNAs (lncRNAs) PlncRNA-1 Colorectal cancer (CRC) Progression PI3K/Akt |
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