经尿道膀胱肿瘤整块切除术治疗初发非肌层浸润性膀胱癌的安全性及疗效分析

Objective　To evaluate the safety and efficacy of transurethral en bloc resection of bladder tumor (ERBT) in the treatment of primary non-muscular invasive bladder cancer (NMIBC). Methods　The clinical data of 67 patients with primary NMIBC were analyzed retrospectively, including 31 cases of ERBT and 36 cases of TURBT. The operation time, hospital stay, indwelling catheter time, bladder muscle layer, bladder perforation, obturator nerve reflex and recurrence-free survival rate were compared between the two groups. Results　The operation time of ERBT group and TURBT group was (39.8±9.76) min vs. (30.4±8.25) min (P=0.001), the hospital stay was (3.6 ±1.0) days vs. (4.3 ±0.9) days (P=0.003), and the indwelling catheter time was (2.4 ±0.7) days vs. (2.8 ±0.6) days (P=0.010), respectively. The existence rate of bladder muscle layer in ERBT group was 96.8%, which was significantly higher than that in TURBT group (77.8%)(P=0.031). The incidence of intraoperative obturator nerve reflex in the ERBT group was 0%, which was significantly lower than that in the TURBT group (16.7%)(P=0.027). There was 1 case of bladder perforation in ERBT group and 4 cases in TURBT group, and there was no significant difference between the two groups (P=0.363). The 1-year recurrence-free survival rate (RFS) of the ERBT group was 88.7%, while that of the TURBT group was 82.5%, but the difference was not statistically significant (P=0.397). Conclusion　ERBT has shorter hospitalization time and catheter indwelling time, lower incidence of obturator nerve reflex, better safety and remarkable curative effect in patients with newly diagnosed NMIBC, which is worthy of clinical promotion.

The safety and efficacy of transurethral en bloc resection of bladder tumor in the treatment of primary non-muscular invasive bladder cancer