养寿丹改善学习记忆功能的实验研究

目的：观察养寿丹对实验动物学习记忆功能的影响。方法：采用避暗法、跳台法和水迷路法研究养寿丹对正常幼龄小鼠及正常幼龄大鼠被动反应、樟柳碱所致小鼠记忆获得障碍，氢溴酸东莨菪碱所致小鼠记忆获得障碍、戊巴比妥钠所致小鼠方向辨别障碍及对老龄小鼠被动回避反应障碍的影响。结果：养寿丹能减少正常幼龄小鼠、正常幼龄大鼠５ｍｉｎ内学习试验及记忆测验的错误次数（Ｐ〈０．０５，Ｐ〈０．０１），可提高戊巴比妥钠造成的方向辨

Studies on Improving the Ability of Learning and Memories of Yangshoudan

OBJECTIVE: To observe the effects of Yangshoudan(YSD) on the ability of learning and memories in experimental animals. METHODS: The tests of darkness-avoidance response in normal young mice and rats, aged mice, as well as in model mice with dysmnesia induced by anisodine, model rats with dysmnesia induced by scopolamine hydrobromide and with orientation disturbance induced by pentobarbital sodium. RESULTS: In normal young mice and rats, the error times in five minutes in learning and memories tests was reduced (P < 0.01-0.05) by YSD, while in dysmnesia groups the error times in five minutes also reduced (P < 0.01-0.05) and the incubation period of memories could be shortened by YSD. In orientation disturbance mice, the averages and percentages of correct response times increased by YSD. CONCLUSIONS: YSD could improve the memory ability both in normal and dysmnesia which either induced by drugs or due to age. This indicates primarily that YSD has the effects of improving the ability of learning and memories and of antidementia.