| Effect of Captopril on Antithrombus Function of Endothelium |
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| 作者姓名： | 熊一力 赵华月 |
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| 作者单位： | Department of Medicine，Tongji Hospital，Tongji Medical University，Wuhan 430030 |
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| 摘 要： | ＥｆｆｅｃｔｏｆＣａｐｔｏｐｒｉｌｏｎＡｎｔｉｔｈｒｏｍｂｕｓＦｕｎｃｔｉｏｎｏｆＥｎｄｏｔｈｅｌｉｕｍＸＩＯＮＧＹｉ－ｌｉ（熊一力）；ＺＨＡＯＨｕａ－ｙｕｅ（赵华月）（ＤｅｐａｒｔｍｅｎｔｏｆＭｅｄｉｃｉｎｅ，ＴｏｎｇｊｉＨｏｓｐｉｔａｌ，Ｔｏｎｇ...
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| 收稿时间： | 13 July 1995 |
Effect of captopril on antithrombus function of endothelium |
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| Xiong Yi-li,Zhao Hua-yue.Effect of Captopril on Antithrombus Function of Endothelium[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1995,15(4):217-219. |
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| Authors: | Xiong Yi-li Zhao Hua-yue |
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| Institution: | (1) Department of Medicine, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Present address: Department of Pharmacology, Tongji Medical University, 430030 Wuhan |
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| Abstract: | The experimental models of cultured porcine aortic endothelial cells(EC) in vitro were established. 6-keto-prostaglandin F1a(6-keto-PGF1a), thromboxane B2(TXB2) content, plasminogen activator(P A), plasminogen activator inhibitor(PAI) activity in cultured medium and cyclic adenosine monophosphate(cAMP) level in EC were measured with radioimmunoassay (RIA), chromogenic substrates methods, in order to assess the effect and mechanism of captopril(CP) on antithrombus function of EC. The results showed that after administration of CP, the contents of 6-keto-PGF1a and cAMP and PA activity were significantly higher, PAI activity were remarkably lower than those of control group. These effects were dose-dependent. Our finding indicated that CP might act as a prospective drug for antithrombosis through promoting anticoagulation and fibrinolysis function and increasing antithrombus action of EC. |
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| Keywords: | captopril endothelium cultured cell |
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