| P-糖蛋白及其逆转肿瘤细胞多药耐药性的研究进展 |
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| 引用本文： | 王清,刘倩,张学梅. P-糖蛋白及其逆转肿瘤细胞多药耐药性的研究进展[J]. 中国执业药师, 2013, 10(3): 33-36,56 |
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| 作者姓名： | 王清 刘倩 张学梅 |
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| 作者单位： | 大连大学医学院,辽宁大连116622 |
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| 基金项目： | 国家科技支撑计划项目课题（2009BAK61B04） |
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| 摘 要： | 随着化疗药物的广泛使用，肿瘤多药耐药性是导致化疗失败的主要原因之一。而p-糖蛋白（P-gp）介导的多药耐药性已成为目前的研究热点，本文就P—gp的结构、组织分布、P—gp介导的肿瘤细胞的多药耐药性及其逆转的研究现状作一综述。
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| 关 键 词： | P-糖蛋白 肿瘤细胞 多药耐药性 |
P-glycoprotein and the Research Progress on Reversal of P-glycoprotein-mediated Multidrug Resistance of Tumor Cells |
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| Wang Qing,Liu Qian,Zhang Xuemei. P-glycoprotein and the Research Progress on Reversal of P-glycoprotein-mediated Multidrug Resistance of Tumor Cells[J]. China Licensed Pharmasist, 2013, 10(3): 33-36,56 |
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| Authors: | Wang Qing Liu Qian Zhang Xuemei |
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| Affiliation: | (Medical College of Dalian University, Liaoning Dalian 116622, China) |
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| Abstract: | With the wide use of chemotherapy drugs, multidrug resistance （MDR） is considered as one of the major reasons causing chemotherapy failure. The multidrug resistance mediated by P-glycoprotein （P-gp） has recently become a hot research topic. This paper briefly introduced the structure and organization distribution of P-gp and the research progress of P-gp mediated multidrug resistance of tumor cells and its reversal strategy. |
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| Keywords: | P-glycoprotein （P-gp） Tumor Cell Multidrug Resistance （MDR） |
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