| Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer’s disease |
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| 作者姓名： | Lian-Feng Lin Min-Jing Liao Xiao-Yan Xue Wei Zhang Li Yan Liang Cai Xiao-Wen Zhou Xing Zhou Huan-Min Luo |
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| 作者单位： | Department of Pharmacology,School of Medicine, Jinan University;Department of Laboratory Medicine, Medical College of Hunan Normal University;Ganzhou People’s Hospital;Department of Pharmacology ,School of Medicine, Jinan University;Institute of Brain Sciences, School of Medicine, Jinan University;The Joint Laboratory of Brain Function and Health, Jinan University and The University of Hong Kong, Jinan University |
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| 基金项目： | supported by the National Natural Science Foundation of China(30672450);the National Basic Research Development Program(973Program)of China(2011CB707500) |
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| 摘 要： | There is no effective drug to treat Alzheimer’s disease (AD), a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta (Aβ) may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors (NTFs). Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.
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| 关 键 词： | Alzheimer’s disease amyloid-beta neurotrophic factors treatment |
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