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FCGR3A V(176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population |
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| Authors: | Aniel J L Brambila-Tapia Jorge I G??mez-Nava Laura Gonz??lez-L??pez Lucila Sandoval-Ram??rez Julio Med??na-D??az Montserrat Maldonado Sergio R Gutierrez-Ure?a Gloria Mart??nez-Bonilla Beatriz T Mart??n-M??rquez M??nica V??zquez del Mercado Arnulfo Nava-Zavala Jos?? F Mu?oz-Valle Mario Salazar-P??ramo Ingrid P D??valos-Rodr??guez |
| Institution: | 1. Doctorado en Gen??tica Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, M??xico 2. Centro de Investigaci??n Biom??dica de Occidente (CIBO, IMSS), Guadalajara, Jalisco, M??xico 7. Unidad de Investigaci??n en Epidemiolog??a Cl??nica (CMNO, IMSS), Guadalajara, Jalisco, M??xico 5. Servicio de Reumatolog??a, Hospital General Regional, No. 110, IMSS, Guadalajara, Jalisco, M??xico 3. Divisi??n de Biolog??a Molecular, Hospital Civil de Guadalajara ??Fray Antonio Alcalde??, Guadalajara, Jalisco, M??xico 4. Servicio de Reumatolog??a, Hospital Civil de Guadalajara ??Fray Antonio Alcalde??, Guadalajara, Jalisco, M??xico 6. Unidad de Investigaci??n en Enfermedades Reum??ticas y Musculoesquel??ticas, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, M??xico |
| Abstract: | The objective of this study is to establish whether there is an association between the presence of FCGR3A V(176) polymorphism with SLE or its manifestations. We included 94 patients according to the 1982 ACR criteria as well as 98 controls matched by age and gender. The 11 ACR diagnostic criteria were analyzed on the clinical files. The polymorphism FCGR3A V(176) was determined by direct sequencing. There was not an association between the polymorphism FCGR3A V(176) with SLE or its main manifestations. The allelic frequency for F(176) was: 0.80 and 0.72 in cases and controls, respectively (P?=?0.09, IC95%: 0.42?C1.07); and the genotypic frequency in the group of cases was: 0.65 for homozygotes F(176)/F(176), 0.30 for heterozygotes and 0.05 for the homozygotes V(176)/V(176), while for the control group it was 0.53, 0.39 and 0.08, respectively. The polymorphism FCGR3A V(176) is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico. |
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