首页 | 本学科首页   官方微博 | 高级检索  
     


Selective serotonin reuptake inhibitor exposure during early pregnancy and the risk of birth defects
Authors:Gentile S
Affiliation:Department of Mental Health ASL Salerno, Mental Health Center Cava de' Tirreni, Salerno, Italy. salvatore_gentile@alice.it
Abstract:Gentile S. Selective serotonin reuptake inhibitor exposure during early pregnancy and the risk of birth defects. Objective: To assess the methodological value of studies that signaled one or more selective serotonin reuptake inhibitors (SSRIs) as teratogenic agents. Method: Medical literature, published in English (1980–November 2010), was searched using MEDLINE/PubMed, TOXNET, EMBASE, and The Cochrane Library to identify all articles, reporting primary data that suggested any increased rate of congenital malformations following prenatal exposure to SSRIs as a group or single SSRI agents. Results: Reviewed studies showed some severe methodological limitations, such as data coming from retrospective studies and incomplete information available with reference to timing of exposure and dosages. Further, data continue to be extrapolated from automated databases that do not declare whether the women reported actually used the prescribed medication. Further, it should be noted the distinct lack of research analysis available with reference to the potential impact of non‐iatrogenic confounders on pregnancy. Conclusion: In light of such considerations, the hypothesized teratogenicity of SSRIs remains undemonstrated. Hence, further, well‐designed research is needed to differentiate definitively the detrimental impact of depression on pregnancy outcomes from potential iatrogenic events.
Keywords:antidepressants  pregnancy  selective serotonin reuptake inhibitors  teratogenesis  review of the literature
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号