| 银杏叶片对人药物代谢酶CYP2A6、XO和NAT2活性的影响 |
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| 引用本文： | 卢新建,张鉴,初建设. 银杏叶片对人药物代谢酶CYP2A6、XO和NAT2活性的影响[J]. 齐鲁药事, 2009, 28(5): 297-300 |
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| 作者姓名： | 卢新建 张鉴 初建设 |
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| 作者单位： | 1. 淄博市齐鲁石化中心医院,山东,淄博,255400
2. 山东省立医院临床药理中心,山东,济南,250021 |
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| 摘 要： | 目的探讨银杏叶片对人肝脏药物代谢酶CYP2A6、XO和NAT2活性的影响,预测银杏叶片与常用药物的相互作用,指导临床合理用药.方法以咖啡因作为药物代谢酶CYP2A6、XO和NAT2的探针药物,以反相高效液相梯度洗脱法测定30名受试者服用银杏叶前后人尿液内咖啡因5种主要代谢物的相对含量,采用代谢物的比率分别评价人肝脏药物代谢酶CYP2A6、XO和NAT2活性的变化.结果受试者服药前CYP2A6、XO和NAT2平均活性为0.227±0.076、0.723±0.060和0.447±0.172;服用银杏叶片28d后CYP2A6、XO和NAT2平均活性为0.227±0.072、0.728±0.074和0.391±0.147;服药前后酶CYP2A6、XO的活性无显著性差异,酶NAT2的活性有显著性差异.结论银杏叶片可能不会影响其他经CYP2A6、XO酶代谢的药物临床疗效,但是可以影响与之合用经NAT2代谢的药物临床疗效.
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| 关 键 词： | 银杏叶片 咖啡因代谢物 细胞色素P4502A6 黄嘌呤氧化酶 N-乙酰基转移酶2 反相高效液相 |
Effect of ginkgo biloba tablets on Cytochrome P4502A6,XO and N-acetyltransferase 2 activity in human |
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| LU Xin-jian,ZHANG Jian,CHU Jian-she. Effect of ginkgo biloba tablets on Cytochrome P4502A6,XO and N-acetyltransferase 2 activity in human[J]. qilu pharmaceutical affairs, 2009, 28(5): 297-300 |
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| Authors: | LU Xin-jian ZHANG Jian CHU Jian-she |
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| Affiliation: | QILU Petro-chemical Central Hospital;Zibo 255400;1.The Center of Clinical Pharmacology;Shandong Provincial Hospital;Ji'nan 250021 |
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| Abstract: | OBJECTIVE To investigate the effect of ginkgo biloba tablets on Cytochrome P4502A6(CYP2A6),Xanthine oxidase(XO),N-acetyltransferase 2(NAT2)activiy in human and to forecast the drug-drug interaction with it,so as to instruct clinical to prescribe rationally.METHODS In thirty volunteers,use two way cross design,caffeine was used as a metabolic probe for CYP2A6,XO,NAT2,before and after ginkgo biloba tablets administration,urine samples were collected.The contents of five major metabolites of caffeine in the ur... |
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| Keywords: | Ginkgo Biloba Tablets caffeine metabolites Cytochrome P4502A6 Xanthine oxidase N-acetyltransferase 2 RP-HPLC |
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