奥美沙坦酯对原发性高血压患者血流动力学的影响

目的观察奥美沙坦酯对原发性高血压患者血流动力学的影响。方法 32例原发性高血压患者(奥美沙坦组)服用奥美沙坦20~40 mg/d10个月,另选30例原发性高血压患者服用复方降压片作为对照组,观察治疗前、后血流动力学指标的变化。结果奥美沙坦组服用奥美沙坦10个月后血压明显下降(P<0.01),全血低切黏度(ηb)、血浆黏度(ηp)及红细胞聚集指数(AI)全血低切还原黏度红细胞电泳纤维蛋白原(Fib)均显著降低(P<0.01);全血高切黏度、全血高切还原黏度、红细胞比容和红细胞刚性指数(RRI)也有所下降,但无统计学意义(P>0.05)。对照组治疗后仅ηb、ηp及AI较治疗前显著降低。结论原发性高血压患者服用奥美沙坦酯后在血压显著降低的同时,其红细胞聚集性Fib下降和红细胞变形能力增强,红细胞比容、血黏度降低。

Clinical effect of olmesartan on hemorrheology in essential hypertensive patients

Objective To investigate the clinical effect of olmesartan on hemorrheology in essential hypertensive patients.Methods Thirty-two essential hypertensive patients received olmesartan,20-40 mg/d for ten months.Thirty essential hypertensive patients who received Fu Fang Jiang Ya Pian were assigned to control group.Then the changes of hemorrheology indexes were tested in both groups.Results After the treatment with olmesartan,the blood pressure reduced effectively(P<0.01),the whole blood low shear rate,hyper viscosity(ηb),plasma viscosity,AI,and whole blood low shear rate reduced.Viscosity,erythrocyte electrophoresis,and fib reduced obviously(P<0.01),but the control group showed no statistically significant differences(P>0.05) before and after treatment.The whole blood high shear rate hyper viscosity,whole blood high shear rate reduced viscosity,Hct,RRI had reduced too(P>0.05).After treatment,only ηb,ηp and AI in the control group were significantly reduced.Conclusion Olmesartan can effectively reduce blood pressure.At the same time,it can improve RBC deformation capability,reduce erythrocyte aggregation,Fib,Hct of essential hypertensive patients,and reduce blood viscosity.