阿司匹林联合阿托伐他汀预防脑梗死复发临床疗效分析

目的研究抗血小板药物阿司匹林与阿托伐他汀联合用药对预防脑梗死复发的临床效果。方法将116例脑梗死患者随机分成2组,均给予脑梗死首发常规治疗,治疗组同时口服阿托伐他汀钙20 mg/d及阿司匹林肠溶片100 mg/d,对照组仅晚间口服阿司匹林肠溶片100 mg/d。比较治疗12个月后2组患者的脑梗死复发率及治疗前后颈动脉斑块变化情况。结果治疗12个月后,治疗组复发率(5.2%)显著低于对照组(19.0%),治疗组不稳定斑块率(24.1%)亦显著低于对照组(41.4%)。结论阿司匹林与阿托伐他汀联合用药后可降低脑梗死患者复发率及不稳定斑块率,其在预防脑梗死复发事件上具有明显的作用。

Effect of aspirin combined with atorvastatin on prevention of the recurrence of cerebral infarction

Objective To study the clinical effect of the combination of aspirin and atorvastatin on prevention of the recurrence of cerebral infarction.Methods A total of 116 patients were randomly divided into two groups.After conventional treatment of first cerebral infarction of two groups,the treatment group received atorvastatin calcium tablets and aspirin enteric-coated tablets together,while the control group only received aspirin enteric-coated tablets at night.The recurrence rates of cerebral infarction and the variation of carotid artery plaque of two groups after 12 months were compared.Results After 12 months,the recurrence rate of the treatment group(5.2%) was significantly lower than that of the control group(19.0%).The carotid artery plaque rate of the treatment group(24.1%) was also significantly lower than that of the control group(41.4%).Conclusion The combination of aspirin and atorvastatin can decrease the recurrence rate and unstable plaque rate of patients,it plays an important part in prevention of recurrence of cerebral infarction.