对比敏感度在糖尿病视网膜病变围激光期的检测意义

目的:探讨对比敏感度(contrast sensitivity,CS)在糖尿病视网膜病变围激光期的检测意义。方法:所有糖尿病视网膜病变患者激光前后行CS和视力、眼底血管造影检查,并根据FFA分为非增殖期(25眼),增殖前期(27眼)和增殖期(35眼),采用532激光进行全视网膜光凝,一般每眼分3～4次完成,比较激光前后的视力和CS的变化。结果:激光后视力提高者22眼(35.48%),不变者34眼(54.84%),下降者6眼(9.68%)。光凝组两期激光前后,在低频、中频、高频时差异均有统计学意义(P<0.05),光凝组激光前与对照组比较,中频、高频均有统计学差异(P<0.05);激光后与对照组比较,在增殖前期时低中频无明显差异(P>0.05),增殖期各空间频率仍有统计学差异(P<0.05)。结论:CS能有效地评估糖尿病视网膜病变的进展变化,是糖尿病视网膜病变行全视网膜光凝的重要指征和有力证据。

Significance of contrast sensitivity for diabetic retinopathy between the stage of pan retinal photocoagulation

AIM: To explore the significance of contrast sensitivity(CS)for diabetic retinopathy(DR)between the stage of pan retinal photocoagulation(PRP).

METHODS: A total of 49 case(87 eyes)of DR was divided into three stages by the fundus fluorescein angiography(FFA), the first group was the stage of non-proliferative diabetic retinopathy(NPDR)(25 eyes), the second group was the stage of pre-proliferative diabetic retinopathy(PPDR)(27 eyes), the third group was the stage proliferative diabetic retinopathy(PDR)(35 eyes). 532nm laser was used to have PRP for the PPDR and PDR groups, and retreated for 3-4 times, the CS and eye sight was performed around the stage of PRP.

RESULTS: After the laser, the eye sight was increased in 22 eyes, decreased in 6 eyes and unchanged in 34 eyes. There were significant differences around the stage of PRP in CS. The differences in middle and high frequency were significant(P<0.05)between the control group and the laser group before PRP. After PRP, low and middle frequency had no significant difference(P>0.05)between PPDR and control group, and each frequency had significant difference(P<0.05)between PDR and control group.

CONCLUSION: CS is an important method of evaluation of the changes the DR, and can become the guiding and proof of PRP in the treatment of DR.