乌司他丁、低分子肝素联合治疗急性胰腺炎的疗效观察

目的观察乌司他丁、低分子肝素联合治疗急性胰腺炎的临床疗效并与2者单用进行对照研究。方法将120例急性胰腺炎患者分为4组,对照组仅接受常规治疗,乌司他丁组患者在常规治疗基础上加用乌司他丁治疗,低分子肝素组加用低分子肝素治疗,联合组在常规治疗基础上加用乌司他丁联合低分子肝素治疗,记录并对照研究4组的临床疗效。结果乌司他丁组及低分子肝素组患者治愈时间均显著短于对照组,联合组治愈时间显著低于其他3组,且总体转归优于对照组,但重症化、手术以及死亡例数各组间比较无显著差异。联合组患者治疗后1、3、7 d的血清CRP水平均显著低于对照组,乌司他丁组及低分子肝素组患者仅治疗后7 d显著低于对照组。结论乌司他丁联合低分子肝素治疗急性胰腺炎疗效更优,可以作为治疗急性胰腺炎的推荐用药方案。

Clinical observation of ulinastatin combined with low molecular weight heparin in the treatment of acute pancreatitis

Objective The compare the efficacies between ulinastatin combined with low molecular weight heparin(LMWH) and individual application of ulinastatin and LMWH in the treatment of acute pancreatitis.Methods A total of 120 patients with acute pancreatitis were divided into four groups.The control group received conventional treatment only,the ulinastatin group received ulinastatin on the basis of conventional therapy,LMWH group received LMWH,and the combined group received ulinastatin and LMWH in addition to conventional therapy.The clinical efficacies of four groups were observed.Results The healing duration in ulinastatin group and the LMWH group was significantly shorter than that of the control group.The combined group was significantly lower than the other three groups,and the overall outcome was better than that of control group.However,myasthenia and surgery,as well as the number of deaths showed no significant difference among the groups.The average 1,3,7 d serum CRP water was significantly lower in the combined group than in the control group.Only 7 days after the treatment of ulinastatin group and LMWH group was significantly lower than that of the control group.Conclusion Ulinastatin combined with LMWH is more efficient,which can be used as recommended regimen for the treatment of acute pancreatitis.