| 幽门螺杆菌与胃部恶性肿瘤 |
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| 引用本文： | 庄园,石云,邹全明. 幽门螺杆菌与胃部恶性肿瘤[J]. 中国肿瘤临床, 2008, 35(24): 1425-1428 |
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| 作者姓名： | 庄园 石云 邹全明 |
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| 作者单位： | 重庆市生物制药工程技术研究中心,第三军医大学临床微生物及免疫学教研室,重庆市,400038 |
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| 基金项目： | 本文课题受国家自然科学基金 ， 重庆市自然科学基金资助 |
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| 摘 要： | 幽门螺杆菌（Helicobacter pylori,Hp）是非贲门胃腺癌和胃粘膜相关淋巴样组织（MALT）淋巴瘤最重要的危险因子。目前普遍认为Hp根除治疗是肠化生发生之前行之有效的治疗手段。然而单一根除Hp只能一定程度减缓胃癌的发病率。Hp与胃部恶性肿瘤之间的关系尚未明了,Hp的致癌效应涉及Hp与胃上皮细胞粘附、Ⅳ型分泌系统促进代谢物易位导致的胃上皮细胞的信号转导途径改变等方面。本文从流行病学、治疗方法学以及发病机制等方面对幽门螺杆菌与胃部恶性肿瘤的研究近况进行综述。
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| 关 键 词： | 幽门螺杆菌 胃癌 MALT淋巴瘤 |
Helicobacter pylori and Gastric Malignancies |
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| ZHUANG Yuan,SHI Yun,ZOU Quanming. Helicobacter pylori and Gastric Malignancies[J]. Chinese Journal of Clinical Oncology, 2008, 35(24): 1425-1428 |
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| Authors: | ZHUANG Yuan SHI Yun ZOU Quanming |
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| Affiliation: | ZHUANG Yuan,SHI Yun,ZOU Quanming Laboratory of Clinic Microbiology , Immunology,The Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Helicobacter pylori(Hp) has been confirmed as the most important risk factor for non-cardia gastric ade-nocarcinomas and gastric mucosa-associated lymphoid tissue(MALT) lymphomas.Eradication therapy has proven beneficial when given prior to the development of intestinal metaplasia.However,Hp eradication alone will have only a moderate effect on gastric cancer incidence worldwide.The mechanisms between Hp and gastric malignancies have not yet been fully illuminated.The pro-carcinogenic effects of Hp could be... |
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| Keywords: | Helicobacter pylori Gastric cancer MALT lymphoma |
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