妊娠高血压综合征与蛋氨酸合成酶还原酶（MSR）A66G基因多态与Hcy水平的关系

目的 探讨妊娠高血压综合征与蛋氨酸合成酶还原酶（MTRR）A66G基因及血浆同型半胱氨酸（Hcy）水平的关系．方法 运用多聚酶链反应-限制性内切酶片段长度多态性技术（PCR-RFLP）检测54例妊高征患者、100例正常妊娠妇女MSR A66G基因多态性，采用荧光偏振免疫法（FPI A）测定血浆总Hcy水平．结果 MSR A66G三种基因型频率与对照组相比差异无显著性．妊高征组总Hcy水平明显高于正常妊娠组（P〈0．05）．结论 MSR A66G基因突变与妊高征发生无关．

Investigation of the Relationship between Polymorphism of Methionine Synthase Reductase and Pregnancy Induced Hypertension syndrome

Objective To investigate the correlation between A66G polymorphism of methionine synthase reductase (MTRR) and the incidence of pregnancy induced hypertension syndrome. Methods We analyzed the A66G polymorphism of MTRR in pregnancy women of normal and PIH by means of PCR and RFLP. Results There were no siganificant differences in the frequenceies of methionine synthase reductase mutations between the patients and central groups , The level of tHcy in pregnancy women of PIH was much more than that in pregnancy women of normal group. Conclusions The point mutation of A66G of MTRR may have no relationship with PIH.