| 孤独症谱系障碍动物模型的研究进展 |
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| 引用本文： | 胡纯纯,徐秀.孤独症谱系障碍动物模型的研究进展[J].中国循证儿科杂志,2015,10(6):463-469. |
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| 作者姓名： | 胡纯纯 徐秀 |
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| 作者单位： | 复旦大学附属儿科医院 上海，201102 |
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| 摘 要： | 孤独症谱系障碍是一种神经发育障碍性疾病。其病因多样，多数认为是环境与遗传的共同结果。动物模型，作为孤独症谱系障碍疾病的研究工具，通过生化作用诱导与基因分子缺陷，从而获得不同的孤独症动物亚型，以研究孤独症的病因，行为学表型，探索药物及干预疗法的安全性和有效性，以期提高孤独症个体的生活质量。
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| 收稿时间： | 2015-06-10 |
| 修稿时间： | 2015-12-24 |
Current progress in animal models of autism spectrum disorders |
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| HU Chun-chun,XU Xiu.Current progress in animal models of autism spectrum disorders[J].Chinese JOurnal of Evidence Based Pediatrics,2015,10(6):463-469. |
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| Authors: | HU Chun-chun XU Xiu |
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| Institution: | Children's Hospital of Fudan University, Shanghai 201102, China |
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| Abstract: | ASD is a neurodevelopmental disorder, with different etiologies. .Generally, it’s a combination of environmental factors and genes. As a research tool, animal models play an important role in ASD research by using biological and genetic molecular defects inducement, to gain more understanding of the mechanism, behavioral phenotype, medication and intervention of the disease, thus raising hope to improve the quality life of autism individuals. |
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