2型糖尿病患者功能磁共振成像的局部脑区活动时空四维一致性

目的:利用功能磁共振成像（fMRI）及临床资料研究2型糖尿病（T2D）患者脑功能及血糖指标改变状况。方法:采集T2D患者（34例）及健康被试（37例）的fMRI信号，计算局部脑区神经活动时空四维一致性指标（FOCA），采集被试者临床实验室检查信息，并分析二者的相关性。结果:与健康对照组相比，T2D患者的FOCA值在左侧颞中回、右侧颞上回显著降低，在右侧小脑显著增加。左侧颞中回的FOCA值与空腹血糖指标、餐后血糖指标呈现显著的负相关。结论:T2D患者会出现右侧小脑、右侧颞上回、左侧颞中回等脑区自发神经活动的紊乱，且左侧颞中回的活动异常与T2D患者空腹及餐后2 h血糖水平等指标具有相关性。

Four-dimensional (spatio-temporal) consistency of local neural activity in type 2 diabetes patient on fMRI

Abstract: Objective To investigate the abnormities in the brain function and plasma glucose level of type 2 diabetes (T2D) patients by functional magnetic resonance imaging (fMRI) and clinical data. Methods The fMRI signals of 34 T2D patients and 37 healthy controls were collected. The four-dimensional (spatio-temporal) consistency (FOCA) of local neural activities was calculated. The information of clinical laboratory examination of subjects was also collected, and the correlations between FOCA and clinical information were analyzed. Results Compared with that of healthy controls, the FOCA of T2D patients was significantly decreased in left middle temporal gyrus and right superior temporal gyrus, while increased in right cerebellum. The FOCA of left middle temporal gyrus was negatively correlated to fasting plasma glucose and postprandial blood glucose. Conclusion T2D patients have abnormal spontaneous neural activities in certain brain areas which includes right cerebellum, right superior temporal gyrus and left middle temporal gyrus, and the abnormal activity of left middle temporal gyrus is related to fasting blood glucose and two-hour postprandial plasma glucose in T2D patients.