早产儿生后2周粪钙卫蛋白动态变化及其影响因素

目的了解早产儿生后2周粪钙卫蛋白(FC)水平及其影响因素。方法 纳入2011年3~6月南京大学第一附属医院及温州医科大学附属乐清医院新生儿科住院的早产儿病例，排除严重的胃肠和全身疾病者。采集早产儿生后2、3、4、5、6、7和14 d的7个日龄粪便标本，采用ELISA法测定FC水平。结果 42例早产儿进入分析，其中男25例，女17例，中位胎龄34.5（28～36.4）周，中位出生体重2 200（930~3 200）g。①胎粪（生后2 d）FC水平为(84.7±15.8) μg·g-1，3~7、14 d FC水平分别为(76.5±12.4)、(86.0±17.6)、(77.5±17.4)、(82.2±15.5)、(84.3±16.1)和（80.3±19.6）μg·g-1；7个日龄FC水平总体差异无统计学意义。②胎粪FC水平剖宫产儿显著低于自然分娩儿，差异有统计学意义(t=-2.56, P=0.01)，生后2周内不同日龄FC水平与性别、孕龄及出生体重无显著相关性；生后3～14日龄FC水平还与分娩方式无显著相关性。结论 生后2周早产儿不同日龄FC水平相近，分娩方式对胎粪FC水平有影响。

Dynamic changes and influence factors of fecal calprotectin within 2 weeks of life in preterm newborns

Objective To study the baseline level of fecal calprotectin (FC) and the factors that may affect the FC levels in preterm newborns within 2 weeks of life. Methods Preterm newborns were recruited from March 2011 to May 2011 from Yueqing Hospital Affiliated to Wenzhou Medical University and The first affiliated Hospital of Nanjing Medical University. Neonates who were suffered from severe gastrointestinal disease and the other severe didease were excluded. Feces were collected in 2, 3, 4, 5, 6, 7, 14 days of life. FC was detected by ELISA. Results A total of 42 patients including 25 males were recruited with the median gestational age (GA) of 34.5(28-36.4) weeks and median birth weight (BW) of 2 200(930-3 200) g. ①The mean FC level in meconium was (84.7±15.8) μg·g-1, the mean FC levels in 3, 4, 5, 6, 7, 14 days of life were (76.5±12.4), (86.0±17.6), (77.5±17.4), (82.2±15.5), (84.3±16.1) and (80.3±19.6) μg·g-1, respectively. There was no significant difference of FC level among different days of life in preterm newborns. ② There was significant difference of meconium FC level between caesarean section and natural labor newborns. There was no evidence that the meconium FC was influenced by gender, GA and BW and that FC levels in 3, 4, 5, 6, 7 and 14 days of life were not influenced by age, gender, GA, BW or delivery mode in preterm newborns. Conclusion The FC levels within 2 weeks of life in the preterm newborns did not vary with age. The delivery mode could influence fecal FC.