小儿肺咳颗粒联合环酯红霉素治疗小儿急性支气管炎的临床研究

目的观察小儿肺咳颗粒联合环酯红霉素治疗急性小儿支气管炎的临床疗效。方法选择2018年6月—2019年6月在彭州市妇幼保健计划生育中心就诊的急性支气管炎患儿216例,随机分为对照组和治疗组,每组各108例。对照组口服环酯红霉素干混悬剂,10~15 mg/kg,1次/12 h;治疗组在对照组基础上口服小儿肺咳颗粒,1岁以下患儿2 g/次、1~4岁患儿3 g/次、5~8岁6 g/次,3次/d。两组患儿均治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状改善情况,及超敏C反应蛋白(hs-CRP)、白细胞介素-10(IL-10)和IL-13水平。结果治疗后,对照组和治疗组临床有效率分别为75.93%和93.52%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者体温恢复正常时间、咳嗽消失时间、肺部喘鸣音消失时间均较对照组明显缩短(P<0.05)。治疗后,两组患者hs-CRP、IL-10和IL-13水平均明显降低(P<0.05),且治疗组患者的炎症指标水平显著低于对照组(P<0.05)。结论小儿肺咳颗粒联合环酯红霉素治疗急性小儿支气管炎能够快速缓解症状,改善炎症指标,具有一定的临床推广应用价值。

Clinical study on Xiaoer Feike Granules combined with erythromycin cyclocarbonate in treatment of acute bronchitis in children

New coronavirus (SARS-CoV-2) is highly contagious and has a high fatality rate, and there is no definitive and effective treatment at present. The virus mainly invades the lungs, COVID-19 severe patients have ARDS or septic shock will lead to multiple organ failure. The progression of the new coronavirus pneumonia is closely related to the immune state of patients. Ulinastatin can effectively inhibit the release of inflammatory factors and improve immune status. So we use it to reduce the mortality rate of ARDS and sepsis patients in clinical application. Moreover, Ulinastatin can be used in combination with hormone or Xuebijing to further enhance the clinical efficacy without obvious adverse reactions. So Ulinastatin can be used to reduce the injury in severe COVID-19 patients.