| 氧化苦参碱抗上消化系肿瘤作用的研究进展 |
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| 引用本文： | 张明发,沈雅琴.氧化苦参碱抗上消化系肿瘤作用的研究进展[J].现代药物与临床,2020,43(5):964-968. |
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| 作者姓名： | 张明发 沈雅琴 |
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| 作者单位： | 上海美优制药有限公司, 上海 201204 |
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| 摘 要： | 氧化苦参碱能抑制人胃癌MGC-803细胞移植瘤或人胰腺癌BxPC-3细胞移植瘤在裸鼠体内生长。体外实验发现氧化苦参碱能浓度相关地抑制人胃癌SGC-7901细胞、MGC803细胞、BGC823细胞、MKN-45细胞，人胰腺癌SW1990细胞，人食管癌Eca-109细胞增殖并诱导凋亡。体外实验发现氧化苦参碱能增强化疗药抗人胃癌SGC-7901细胞作用。临床上已试用于食管癌的治疗。
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| 关 键 词： | 氧化苦参碱 胃癌 胰腺癌 食管癌 抗肿瘤 |
| 收稿时间： | 2020/3/22 0:00:00 |
Advances research on antitumor effects of oxymatrine in supper digestive system |
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| ZHANG Mingf,SHEN Yaqin.Advances research on antitumor effects of oxymatrine in supper digestive system[J].Drugs & Clinic,2020,43(5):964-968. |
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| Authors: | ZHANG Mingf SHEN Yaqin |
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| Institution: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201204, China |
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| Abstract: | Oxymatrine inhibits the growth of transplantation tumor of human gastric carcinoma MGC-803 cells, or human pancreatic cancer BxPC-3 cells in nude mice. Oxymatrine inhibits proliferation and induces apoptosis in association with dosage on human gastric carcinoma SGC-7901 cells, MGC803 cells, BGC823 cells, MKN-45 cells, and human pancreatic cancer SW1990 cells, and human carcinoma of esophagus Eca109 cells, in vitro. Oxymatrine can promote the effects of chemotherapeutics against gastric carcinoma SGC-7901 cells in vitro. In clinic oxymatrine has been tried on the treatment of carcinoma of esophagus. |
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| Keywords: | oxymatrine gastric carcinoma pancreatic cancer carcinoma of esophagus antitumor |
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