延伸野调强放疗在局部晚期宫颈癌中的应用

目的:研究体外延伸野调强放疗在局部晚期宫颈癌中的应用价值。方法:120例局部晚期宫颈癌患者（IIB~IVA期）随机分为对照组和观察组，各60例，对照组采用常规同步放化疗方案，观察组采用体外延伸野调强放疗联合同步化疗，5次/周，共8周，随访3年，比较总有效率和毒性反应，局部无进展生存时间（PFS）和生存率。结果:观察组总有效率明显高于对照组，差异有统计学意义（88.3% vs 73.3%, P<0.05）。两组毒性反应发生率和III~IV度百分比差异无统计学意义（P>0.05）。观察组PFS显著延长，生存率提高，差异有统计学意义（P<0.05）。结论:体外延伸野调强放疗在局部晚期宫颈癌中有较好的安全性和有效性。

Application of extended-field intensity-modulated radiotherapy for locally advanced cervical cancer

Abstract: Objective To study the effects of extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer. Methods A total of 120 patients with locally advanced cervical cancer of stage IIB-IVA were randomly divided into control group and observation group, with 60 cases in each group. Conventional synchronous radiochemotherapy was adopted in control group, while extracorporeal extended-field intensity-modulated radiotherapy combined with synchronous chemotherapy was adopted in observation group. The treatment was conducted 5 times per week and for 8 weeks, and the patients were followed-up for 3 years. The total effective rate, toxicity reaction, local progression-free survival and survival rate in two groups were compared. Results The total effective rate of observation group was higher than that of control group (88.3% vs 73.3%, P<0.05), while there was no statistical difference in the occurrence rate of toxicity reaction and percentage of stage III-IV between two groups (P>0.05). Compared with control group, observation group achieved a longer progression-free survival and a higher survival rate, with statistical significance (P<0.05). Conclusion Extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer is proved to be safe and effective.