In vivo measurement of energy metabolism and the concomitant monitoring of electroencephalogram in experimental cerebral ischemia |
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| Authors: | Shoji Naruse Yoshiharu Horikawa Chuzo Tanaka Kimiyoshi Hirakawa Hiroyasu Nishikawa Hiroshi Watari |
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| Affiliation: | 1. Department of Neurosurgery, Kyoto Prefectural University of Medicine, Kyoto 602, Japan;2. Department of Physiology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan;3. Department of Molecular Physiology, National Institute for Physiological Science, Okazaki 444 Japan |
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| Abstract: | The energy metabolites in rat brain in vivo were measured by using topical magnetic resonance (TMR) during the whole course of ischemia, in combination with the concomitant monitoring of electroencephalogram (EEG). Immediate loss of high energy phosphorus compounds, phosphocreatine (PCr) and ATP, resulted in the flattening of EEG after the induction of ischemia. PCr and ATP returned to almost normal level 30 min after recirculation of the ischemic brain, but EEG showed no recovery and the abnormality lasted for 12 h. The measurement of in vivo 31P-NMR is essential for the decision of the convalescence of cellular function in the brain. |
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| Keywords: | nuclear magnetic resonance (NMR) 31P-NMR topical magnetic resonance (TMR) energy metabolism EEG cerebral ischemia convalescence of nerve cells brain death |
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