Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain |
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Authors: | J A Forbes K F Jones C J Kehm W K Smith C M Gongloff J R Zeleznock J W Smith W T Beaver M Kroesen |
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Affiliation: | Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD. |
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Abstract: | Three hundred fifty outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive a single oral dose of aspirin 650 or 1000 mg, caffeine 65 mg, a combination of aspirin 650 mg with caffeine 65 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. Estimates of summed pain intensity difference, peak pain intensity difference, total relief, peak relief, and hours of 50% relief were derived from these subjective reports. All active treatments except caffeine were significantly superior to placebo. Pairwise comparisons indicated the aspirin-caffeine combination was statistically superior to aspirin 650 mg alone for hours of 50% relief among patients who had severe baseline pain. Adverse effects were transitory and none were serious. |
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