血管内皮细胞生长因子和内抑素失衡在2型糖尿病肾病中的作用

目的探讨血管内皮细胞生长因子(VEGF)和内抑素在2型糖尿病肾病(DN)中的作用。方法对30例2型糖尿病无肾病和30例2型DN患者,采用ELISA法检测血清中VEGF和内抑素的浓度变化进行了观察,30例健康成人作为正常对照,并结合临床进行了分析。结果2型糖尿病无肾病和2型DN患者血中VEGF和内抑素的表达与正常人相比均有明显差异(P<0.05,P<0.01),2型DN患者血中VEGF和内抑素浓度的增加与蛋白尿、肾功能及视网膜病变程度密切相关。而与高血压、高血脂及糖化血红蛋白水平之间无统计学意义。结论2型糖尿病无肾病和2型DN患者血中VEGF和内抑素的表达动态的逐渐增加,其增加与2型DN患者的蛋白尿形成、肾功能和糖尿病视网膜病变改变关系密切,VEGF和内抑素参与了2型DN患者血管增生的肾脏病变和功能紊乱发生的作用。

Link of imbalance of vascular endothelial growth factor and endostatin with angiogenesis in patients with type 2 diabetic nephropathy

Objective To investigate the effect of vascular endothelial growth factor(VEGF) and endostatin in type 2 diabetic nephropathy (DN) patients. Methods By enzyme-linked immunosorbent assay,serum concentration of VEGF and endostatin in 30 type 2 DN patients and 30 type 2 diabetic non-nephropathy were detected,serum of 30 health person were used as normal control. Results The serum concentration of VEGF and endostatin were significantly different (P<0.05,P<0.01),between the type 2 diabetic non-nephropathy group and DN group and the normal control. The serum concentration increase of VEGF and endostatin were closely related with the proteinuria,renal function and the diabetic retinopathy in type 2 DN,via they did not show any statistical difference with hypertension,hyperglyceride and glycated hemoglobulin. Conclusion The serum concentration of VEGF and endostatin increase gradually with the progressing of disease in both type 2 diabetic non-nephropathy group and the DN group. VEGF and endostatin are closely related with the proteinuria,renal function and the diabetic retinopathy . VEGF and endostatin may play an important role in the angiogesis of DN and the disturbance of function.