Effects of human T-lymphotropic virus type II on human immunodeficiency virus type 1 phenotypic evolution |
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| Authors: | P. C. Guenthner R. C. Hershow R. B. Lal C. S. Dezzutti |
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| Affiliation: | (1) HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., US;(2) University of Illinois at Chicago, College of Medicine and School of Public Health, Chicago, Illinois, U.S.A., US |
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| Abstract: | Summary. Phenotypic change and broader coreceptor usage by HIV-1 have been associated with disease progression. HIV-1 coreceptor usage by primary isolates obtained from HIV-1-infected and HIV-1/HTLV-II-coinfected individuals was determined. HIV-1 was isolated from 15 of 20 HIV-1-infected and 17 of 24 HIV-1/HTLV-II-coinfected individuals. None of the isolates from either the HIV-1-infected or the coinfected group infected CCR5Δ32 PBMCs, suggesting that they all were R5-tropic. Further, both spontaneous and PHA-stimulated production of MIP-1β and RANTES were similar in HIV-1-infected and coinfected individuals. These data indicate that coinfection with HTLV-II has no effect on HIV-1 coreceptor usage or ex vivo β-chemokine production. Received December 23, 2000/Accepted May 16, 2001 |
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